You can read more about Section 508 here: www.section508.gov.
Per the official government website, the following is a brief description of Section 508:
"In 1998, Congress amended the Rehabilitation Act of 1973 (29 U.S.C. 794d) as amended by the Workforce Investment Act of 1998 (P.L. 105 - 220), August 7, 1998 to require Federal agencies to make their electronic and information technology (EIT) accessible to people with disabilities."
"Specifically, Section 508 of that act requires that when federal agencies develop, procure, maintain, or use EIT, Federal employees with disabilities have access to and use of information and data that is comparable to the access and use by federal employees who are not individuals with disabilities, unless an undue burden would be imposed on the agency."
Once you have reviewed the official website, you may be overwhelmed or confused about what Section 508 means to you. In short, you will find a few basic rules to follow when building and formatting projects.
These are just a few ideas; please always refer to the official site and comply with all rules posted.